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Decreased Time Constant Effects
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Infants with severe pulmonary disease should be ventilated with small tidal volumes because lung heterogeneity and unexpanded alveoli lead to overdistention and injury of the most compliant alveoli if a normal tidal volume is used.
Gas Trapping Etiology
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Insufficient expiratory time may lead to increases in functional residual capacity and inadvertent positive end-expiratory pressure.
Hypoxemia In Newborns Causes
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Hypoxemia usually is the result of ventilation/perfusion mismatch or right-to-left shunting
Neonatal Hypercapnia
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Hypercapnia is primarily the result of hypoventilation.
Respiratory Frequency Effects
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Because dead space ventilation is constant, changes in tidal volume appear more effective at altering carbon dioxide elimination than changes in frequency.
Short Inspiratory Times Effects
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Very short inspiratory times do not allow for adequate tidal volume delivery.
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